CONDITION OF CORONARY ARTERIES IN PATIENTS WITH ACUTE CORONARY SYNDROME CAUSED BY NEWLY IDENTIFIED DISORDERS OF CARBOHYDRATE METABOLISM

Abstract

Introduction. According to the International Diabetes Federation (IDF), in 2021 the number of people with diabetes was 536.6 million people, with prediabetes - 464 million [2]. Diabetes is one of the most common comorbid conditions in patients with coronary heart disease (CHD). The incidence of CHD in patients with type 2 diabetes is ~21%, and the incidence of DM among patients with acute coronary syndrome (ACS) varies from 25 to 30% [3, 4]. Aim. To assess the condition of the coronary bed in patients with ACS against the background of newly diagnosed carbohydrate metabolism disorders (CMD). Materials and methods: а quantitative, cross-sectional study was conducted in 200 patients with acute coronary syndrome without a history of CMD. Based on the results of the study, patients were divided into 3 groups: with T2DM, with prediabetes, and without - the control group. Statistical analysis was performed using the statistical program IBM SPSS Statistics 23. Methods of parametric and nonparametric statistics were used. Differences between groups were considered statistically significant at p<0.05. Results. NDEs were identified in 63% of the examined patients. Multivessel coronary lesions were significantly more common in the group of patients with NUD (81.48%) and amounted to 44.44% in patients with T2DM and 37.03% in prediabetes. Conclusions. Our study confirmed that the presence of NDO is a severe risk factor for coronary artery disease. Prediabetes and T2DM are serious predictors of the development of cardiovascular complications.