CLINICAL SIGNIFICANCE OF SERUM KLOTHO LEVELS IN PATIENTS WITH STEMI AND RENAL DYSFUNCTION

Abstract

Introduction: Renal dysfunction is recognized as a major global public health issue, with an estimated worldwide prevalence of up to 13.4%. Patients with renal dysfunction represent a growing proportion of the PCI population. At the same time, patients with chronic kidney disease are at high risk of adverse cardiovascular events. Objective: To evaluate the relationship between the Klotho protein and traditional cardiovascular risk markers in patients with ST-segment elevation myocardial infarction (STEMI) combined with renal dysfunction. Materials and Methods: Design: Cross-sectional clinical study. Timeline: 2022–2023. Location: The department of Cardiac surgery of the hospital at NJSC “Medical University of Semey.” The study methods included evaluation of residual platelet reactivity and measurement of serum Klotho protein levels. Results: A total of 123 patients were included. An inverse correlation was found between age and Klotho protein level (Rho = –0.673; p < 0.001). A direct correlation was found between estimated glomerular filtration rate (GFR) and serum Klotho (Rho = 0.463; p < 0.001). Additionally, for the first time, a correlation between Klotho and total cholesterol (Rho = – 0.417; p < 0.001) and C-reactive protein (Rho = –0.416; p < 0.01) was demonstrated. Conclusion: In patients with ST-segment elevation myocardial infarction (STEMI) and GFR < 60 mL/min/1.73 m², assessment of serum Klotho levels may serve as an early and independent biomarker of renal dysfunction and a predictor of adverse cardiovascular outcomes.