HE ASSOCIATION OF ERECTILE DYSFUNCTION WITH TRANSPORTERPROTEIN POLYMORPHISM IN ELDERLY KAZAKH MEN
DOI:
https://doi.org/10.34689/q4gjem06Keywords:
Erectile dysfunction, SHPG polymorphism, age-related hypogonadism, overweight, Kazakh menAbstract
Introduction. Transport protein globulin binding sex hormones play an important role in the transport of testosterone to
target cells. Erectile dysfunction in older men is associated with androgen levels.
The aim of the study: is to investigate the association between erectile dysfunction and the polymorphism of the sex
hormone-binding globulin (SHBG) transport protein gene in Kazakh men with age-related hypogonadism.
Materials and Methods. This study aimed to assess the association between single nucleotide polymorphisms (SNPs)
of the SHBG gene rs 727428, rs 5934505 and rs 10822184 and the risk of early-onset erectile dysfunction (ED) in
overweight Kazakh men. A total of 253 Kazakh males were enrolled. The study group comprised 83 individuals exhibiting
signs of erectile dysfunction, as determined by the International Index of Erectile Function-5 (IIEF-5) questionnaire (scores 6
25). The control group included 170 men without signs of ED (IIEF-5 scores 26–30). Genotyping of the SNPs rs727428 [C/T],
rs5934505 [C/T], and rs10822184 [T/C] was performed using the TaqMan assay. Serum levels of high-sensitivity C-reactive
protein (hsCRP), androgen fractions (total testosterone, free testosterone, and bioavailable testosterone), albumin, and lipid
profile parameters (HDL, LDL, triglycerides) were also measured.
Results. Erectile dysfunction in overweight individuals in the main group was associated with the genetic variation
rs5934505 (p=0.004). However, this polymorphic protein is not associated with testosterone concentration or lipid
metabolism. An association was found between rs727428 and albumin (p=0.03) as well as testosterone (p=0.001). The
rs10822184 polymorphism was found to influence LDL (p=0.01) and triglyceride (p=0.04) concentrations.
Conclusions. The earlier onset of erectile dysfunction in overweight Kazakh men is associated with the rs5934505
polymorphism of the SHBG gene. The influence of rs727428 on total testosterone concentration has been confirmed, and
the association of rs10822184 with LDL and triglyceride levels in Kazakh men has been established.
References
Аккалиев М.Н., Жунуспекова А.С., Берікұлы Д., Бухариева С.С., Кудербаев М.Т., Ботабаева А.С., Иманбаев М.Н., Базарбеков Р.Ж. Ассоциация эректильной дисфункции с полиморфизмом транспортного белка у мужчин старшего возраста казахского этноса // Наука и Здравоохранение. 2025. Т.27 (2), С.46-52. doi 10.34689/SH.2025.27.1.006
Akkaliyev M.N., Zhunuspekova A.S., Berikuly D., Bukharieva S.S., Kuderbaev M.T., Botabaeva A.S., Imanbayev M.N., Bazarbekov R.Zh. The association of erectile dysfunction with transporter protein polymorphism in elderly Kazakh men // Nauka i Zdravookhranenie [Science & Healthcare]. 2025. Vol.27 (2), pp. 46-52. doi 10.34689/SH.2025.27.2.006
Аккалиев М.Н., Жунуспекова А.С., Берікұлы Д., Бухариева С.С., Кудербаев М.Т., Ботабаева А.С., Иманбаев М.Н., Базарбеков Р.Ж. Егде жастағы қазақ ер адамдарында эректильді дисфункцияның тасымалдаушы ақуыз полиморфизмімен байланысы // Ғылым және Денсаулық сақтау. 2025. Т.27 (2), Б.46-52. doi 10.34689/SH.2025.27.2.006
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