CLINICAL-FUNCTIONAL AND NUTRITIONAL-METABOLICASPECTS OF VIBRATION DISEASE IN COMBINATIONWITH ARTERIAL HYPERTENSION

Abstract

Introduction. Vibration disease is of fundamental importance in deteriorating the quality of life, requiring regular
monitoring in occupational pathology centers. Currently, early diagnosis, prevention and rehabilitation of patients with
comorbid vibration disease remains an important issue.
Target. Study of diagnostic criteria in patients with a comorbid phenotype of vibration disease in combination with
arterial hypertension under conditions of exposure to vibration in an occupational pathology clinic.
Materials and methods. An intersystem correlation analysis of clinical-functional and nutritional-metabolic
indicators was performed with the relationship determined using the logical regression method. 431 people were
examined, of which: 104 patients diagnosed with stage I vibration disease, 101 patients with vibration disease in
combination with arterial hypertension, 107 patients with stage I-II arterial hypertension who do not have contact with
vibration and 119 people working in the same enterprise out of contact with vibration.
The duration of the study was 5 years. The subjects underwent a complex of clinical, laboratory and functional
studies with special attention to the diagnostic parameters of comorbid pathology. Critical significance level p=0.05.
Results. During the analysis, it was found that the course of vibration disease in conditions of comorbidity affects
the prognosis of an occupational disease. Vibration disease in comorbid conditions, in contrast to isolated vibration
disease, is characterized by a more severe course with worse nutritional-metabolic status, clinical, functional and
laboratory parameters. In patients with the phenotype of vibration disease in combination with arterial hypertension,
the polymorphic variant T/T Ala 16 Val (rs4880) of the copper-zinc superoxide dismutase gene is detected in 30% of
cases, which is 1.9 and 1.2 times higher than in the control and comparison groups respectively.
Conclusion. The course of vibration disease and predicted features depend on the presence of comor bidity, as
well as the intensity and duration of exposure to the production factor of vibration. The combination of vibration
disease and arterial hypertension is a separate phenotype and is characterized by clinical, functional and nutritional -
metabolic features. The acquired knowledge can be used to develop algorithms for early diagnosis and prevention of
vibration disease in combination with arterial hypertension.